科学研究

李欣阳课题组

PI:Xinyang LI

研究方向:成像与视觉,人工智能赋能科学观测

课题组简介

作为视觉的延伸,成像仪器将人类的观测范围扩展到肉眼不可及的尺度和精度,带来一系列科学发现。瞄准成像领域的前沿难题,课题组致力于以人工智能赋能科学观测,推进科学观测极限,并与多个领域深度交叉推动科学发现。研究方向包括:

  • 智能成像与图像分析:研究高性能、可解释、自监督的智能图像分析方法,探索成像仪器与人工智能融合新架构,以智能计算突破观测极限,推动科学发现。

  • 科学观测大模型:构建跨尺度、多模态、高质量的科学观测数据集,发展面向前沿科学研究的基础模型,实现复杂科学现象的精准表征与机理发现。

  • 先进成像机制与系统:研究成像机器人新架构,以具身智能赋能自主感知与主动观测;研究量子效应与光学成像融合新范式,从物理机制上突破观测极限。

代表性论文

[1] Yixin Li, Qi Zhang, Yuanlong Zhang, Jiaqi Fan, Zhi Lu, Xinhong Xu, Xinyang Li#, et al. Unsupervised transfer learning enables multi-animal tracking without training annotation, Nature Methods, 2026.

[2] Xinyang Li*, Yixin Li*, Yiliang Zhou, Jiamin Wu, et al. "Real-time denoising enables high-sensitivity fluorescence time-lapse imaging beyond the shot-noise limit." Nature Biotechnology, 2023.

[3] Xinyang Li*, Yuanlong Zhang*, Jiamin Wu#, Qionghai Dai#. "Challenges and opportunities in bioimage analysis." Nature Methods, 2023.

[4] Xinyang Li*, Guoxun Zhang*, Jiamin Wu, Yuanlong Zhang, et al. "Reinforcing neuron extraction and spike inference in calcium imaging using deep self-supervised denoising." Nature Methods, 2021.

[5] Xinyang Li*, Xiaowan Hu*, Xingye Chen*, Jiaqi Fan, et al. "Spatial redundancy transformer for self-supervised fluorescence image denoising." Nature Computational Science, 2023.

[6] Xinyang Li*, Guoxun Zhang*, Hui Qiao*, Feng Bao, et al. Unsupervised content-preserving transformation for optical microscopy. Light: Science & Applications, 2021.

[7] Zhi Lu*, Wentao Chen*, Feihao Sun, Jiaqi Fan, Xinyang Li, et al. Leveraging spatial-angular redundancy for self-supervised denoising of 3D fluorescence imaging without temporal dependency. Nature Communications, 2025.

[8] Zhifeng Zhao*, Yiliang Zhou*, Bo Liu*, Jing He*, Jiayin Zhao, Yeyi Cai, Jingtao Fan, Xinyang Li, et al. "Two-photon synthetic aperture microscopy for minimally invasive fast 3D imaging of native subcellular behaviors in deep tissue." Cell, 2023.

[9] Guoxun Zhang*, Xiaopeng Li*, Yuanlong Zhang*, Xiaofei Han, Xinyang Li, et al. Bio-friendly long-term subcellular dynamic recording by self-supervised image enhancement microscopy. Nature Methods, 2023.

[10] Yuanlong Zhang*, Guoxun Zhang*, Xiaofei Han, Jiamin Wu, Ziwei Li, Xinyang Li, et al. Rapid detection of neurons in widefield calcium imaging datasets after training with synthetic data. Nature Methods, 2023.

课题组成员

  • 谢佳辰

    xiejc20@mails.tsinghua.edu.cn

  • 李奕昕

    liyixin318@gmail.com

  • 王铁儒

    wtr24@mails.tsinghua.edu.cn

  • 徐子荆

    xuzijinganny@gmail.com

  • 周熙柔

    zhouxrxd@163.com

  • 谷雨桐

    gyt04082888@163.com

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